B-Supreme (Coenzymated B-vitamin complex) - capsules

A comprehensive B vitamin complex formulated with bioidentical and coenzymated forms of B vitamins for enhanced nutrient absorption and bioavailability.

This very powerful B vitamin combination formula supplies most of the B vitamins in their coenzymated forms, so the body does not have to phosphorylate them in order to be used in biochemical reactions. This formula also includes TMG and choline to support methylation.

B-Supreme is a comprehensive B vitamin complex formula designed to promote micronutrient status for optimal cellular function and healthy physiology. It supplies clinically useful amounts of B vitamins in their preferred coenzymated and phosphorylated forms, making them more readily available for biochemical reactions.

This formula also contains bioidentical, methylated forms of folate and vitamin B12 for superior bioavailability. Choline and trimethylglycine (TMG) are included to help support efficient methylation for optimal genetic expression.

Highlights:

• Formulated with bioidentical and coenzymated B vitamins for enhanced absorption and bioavailability

• Features the bioactive form of folate, Quatrefolic® [6S]-5-methyltetrahydrofolate (MTHF), and vitamin B12 as MecobalActive® methylcobalamin

• Choline and TMG added to support methylation pathways

• Vegetable capsule; suitable for vegetarians and vegans

Why B Vitamins Are Important:

B vitamins are water-soluble micronutrients needed in small amounts by the body. They fall into two main categories:

1. Those involved in one-carbon metabolism (single-carbon transfers).

2. Those involved in energy production and redox reactions.

Populations at higher risk of B vitamin deficiencies include:

• Vegans and vegetarians

• Individuals with alcoholism

• Patients with congestive heart failure, obesity, or diabetes

• The elderly

• Individuals who have undergone bariatric surgery

Supplementation with B complex vitamins has been shown to:

• Reduce homocysteine (Hcy) levels (an inflammatory marker in cardiovascular, metabolic, and neurological conditions)

• Slow cognitive decline

• Exhibit analgesic properties via the nitric oxide/cGMP pathway

Benefits:

• Supports B vitamin status in the body

• Promotes optimal intake of essential micronutrients for overall health

• Supports healthy homocysteine metabolism

• May be helpful for individuals following vegan or vegetarian diets

Ingredient Highlights:

• Thiamine (B1): Critical for ATP production, brain and nerve health, and acetylcholine neurotransmission. Deficiency often linked to alcoholism and malabsorption.

• Vitamin B2 (Riboflavin & Riboflavin-5-Phosphate): Crucial in redox reactions, folate metabolism, thyroid regulation, iron absorption, and glutathione recycling. Cofactor for MTHFR enzyme, relevant to homocysteine metabolism.

• Niacinamide (B3): Important for cellular energy and NAD⁺ production, impacting metabolism, circadian rhythm, and brain health.

• Pantothenic Acid (B5): Required for coenzyme A production; supports lipid and triglyceride metabolism.

• Vitamin B6 (as P5P and pyridoxine HCl): Essential in neurotransmitter synthesis (serotonin, dopamine, GABA, etc.); linked to homocysteine metabolism.

• Biotin: Supports skin, hair, nail health, and metabolism of glucose, fats, and amino acids. High doses may improve glycemic control and lipid metabolism.

• Folate (Quatrefolic®): A stable, bioavailable 5-MTHF form; essential for one-carbon metabolism and prevention of hyperhomocysteinemia.

• Vitamin B12 (Methylcobalamin): Bioidentical to physiological B12; supports methylation, mitochondrial enzymes, and cognitive health.

Contraindications

• Avoid high doses of niacin/niacinamide in cases of jaundice, ulcers, gastritis, renal failure, gout, or certain heart conditions.

• Patients on Levodopa should avoid vitamin B6 (can inactivate the drug).

• Lactating women should not exceed 50 mg/day of B6 (may suppress lactation).

• High doses of biotin may interfere with hormone diagnostic assays (e.g., thyroid tests).

• Folate or folic acid should not be combined with methotrexate.

Medicinal Ingredients (per capsule)

• Trimethylglycine (Betaine) – 200 mg

• Pantothenic acid (Calcium d-pantothenate) – 100 mg

• Thiamine (Thiamine HCl) – 100 mg

• Vitamin B2 (Riboflavin, Riboflavin-5-Phosphate sodium) – 50 mg

• Vitamin B3 (Niacinamide) – 50 mg

• Vitamin B6 (Pyridoxal-5-Phosphate, Pyridoxine HCl) – 50 mg

• Choline (Choline dihydrogen citrate) – 30 mg

• Biotin – 2 mg

• Vitamin B12 (Methylcobalamin) – 250 mcg

• Folate ([6S]-5-MTHF, glucosamine salt) – 200 mcg

Non-Medicinal Ingredients: Hypromellose, silicon dioxide, magnesium stearate (vegetable source), stearic acid (vegetable source).

Recommended Dose

• Adults: Take 1 capsule per day with a meal, or as directed by your healthcare practitioner.

• Consult a healthcare practitioner for use beyond 3 months.

THIS INFORMATION IS PROVIDED AS A MEDICAL AND SCIENTIFIC EDUCATIONAL RESOURCE FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ("PRACTITIONERS"). PRODUCT INDICATIONS WITHIN THIS RESOURCE MAY BE DIFFERENT THAN WHAT IS LISTED ON THE LABEL AS PER HEALTH CANADA’S SELF-CARE NATURAL HEALTH PRODUCT REGULATIONS. THIS INFORMATION IS INTENDED FOR PRACTITIONERS TO USE AS A BASIS FOR DETERMINING WHETHER TO RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. ALL RECOMMENDATIONS REGARDING PROTOCOLS, DOSING, PRESCRIBING AND/OR USAGE INSTRUCTIONS SHOULD BE TAILORED TO THE INDIVIDUAL NEEDS OF THE PATIENT CONSIDERING THEIR MEDICAL HISTORY AND CONCOMITANT THERAPIES. THIS INFORMATION IS NOT INTENDED FOR USE BY CONSUMERS.